Harald Guldan

Sen. Manager Technical Operations at Lophius Biosciences Gmbh

Harald Guldan's Professional Contact Details

Email (Verified)

****@lophius.com

Get Email Address

(941) 630-9197

Location

Regensburg, Bavaria, Germany

Company

Lophius Biosciences Gmbh

Person Seniority

manager

Person Functions

operations

Harald Guldan's Current Company Details

Lophius Biosciences Gmbh

Regensburg, Bavaria, Germany • 12 Employees

biotechnology

Lophius Biosciences GmbH is focusing on the development and marketing of innovative T cell based diagnostic systems for the early diagnosis and immunomonitoring in the fields of transplantation, infectious and autoimmune diseases. The company's proprietary platform technologies include i) the T-activationÂ® Technology that significantly increases the immunostimmulatory properties of immunogens as well as ii) the Reverse T cell Technology that allows a more rapid detection of an active vs latent disease status in patients. The Lophius T-activationÂ® Technology facilitates HLA-independent protein uptake, processing, and presentation of both MHC class I and class II (cross-presentation) in APC. As a result, clinically relevant effector cells of cell-mediated immunity (CD4+, CD8+, NK, and NKT cells) will be activated, which allows a very specific and sensitive assessment / monitoring of the functionality of the network of pathogen/disease-reactive effector cells in immunocompromized patients Based on that technology, the company has developed and is currently marketing a CE-marked in-vitro diagnostic (IVD) system: T-TrackÂ® CMV, which is intended to improve prognosis of clinical complications in immunocompromized transplant patients i.e. CMV virus reactivation and transplant rejection. Reverse T cell Technology, another platform technology of Lophius is intended to detect disease pathogen specific activated T helper cells being an immunological marker for an active, ongoing infection or inflammation. The assays are based on the measurement of a pathogen/disease-specific gene activity profile. Applications are early detection and monitoring of autoimmune diseases (e.g. Multiple Sclerosis) and diagnosis of the disease status of microbial infections by discriminating latent infection from an active disease (e.g. Tuberculosis).

Founded Year

2008

Organization Website

lophius.com

Organization Languages

English

Organization Revenue

3400

Current Technologies

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